Edward W. Holt, M.D., Transplant Hepatologist, Director of the Fatty Liver Program at CPMC

California Pacific CURRENTS: The online journal of CPMC Research Institute

Leading research advances and improving patient care in liver diseases

Research Overview

  • Dr. Holt specializes in the treatment of nonalcoholic fatty liver disease (NAFLD) and other liver diseases such as viral hepatitis, autoimmune liver disease, alcoholic liver disease and hepatocellular carcinoma (HCC). He is board certified in internal medicine, gastroenterology, and transplant hepatology.
  • As Director of the Fatty Liver Program at CPMC, Dr. Holt oversees the care of patients with NAFLD and organizes research studies, including clinical trials of new drugs for this disease.
  • Dr. Holt presents locally and nationally on topics including the treatment of nonalcoholic steatohepatitis (“NASH” – liver inflammation caused by a buildup of fat in the liver), acute liver failure, and the impact of obesity on gastrointestinal and liver disease.
  • His research examines the natural history of NAFLD in an ethnically diverse population. Patients seen in CPMC’s Fatty Liver Clinic have the opportunity to participate in prospective cohort studies and in clinical trials. 


Dr. Holt obtained his M.D. from the Medical Uidency training in internal medicine at the Massachusetts General Hospital in Boston, and fellowships in gastroenterology and transplant hepatology at

Publication Search


Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM, Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. Autoimmunity

Dyal HK, Aguilar M, Bartos G, Holt EW, Bhuket T, Liu B, Cheung R, Wong RJ, Diabetes Mellitus Increases Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients: A Systematic Review. Dig Dis Sci

Dyal HK, Aguilar M, Bhuket T, Liu B, Holt EW, Torres S, Cheung R, Wong RJ, Concurrent Obesity, Diabetes, and Steatosis Increase Risk of Advanced Fibrosis Among HCV Patients: A Systematic Review. Dig Dis Sci

Edward W. Holt, M.D., Transplant Hepatologist, Director of the Fatty Liver Program at CPMC
Primary Research Interests
  • Hepatology
  • Liver Transplantation
  • Nonalcoholic Fatty Liver Disease
  • Portal Hypertension
  • Viral Hepatitis
  • Liver Biopsy
  • Colonoscopy

Liver Disease Clinical Trials