Katie L. Stone, Ph.D., Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Improving the understanding of sleep disorders in older adults
  • relationship of hypoxia, sleep fragmentation, and a measure of sleep duration on risk for mild cognitive impairment or dementia

    The study investigated the relationship of hypoxia, sleep fragmentation, and a measure of sleep duration on risk for mild cognitive impairment or dementia. Two measures of hypoxia (an oxygen desaturation index of ≥15 and a high percentage of total sleep time [>7%] in apnea or hypopnea) were associated with higher incidence of mild cognitive impairment or dementia (oxygen desaturation index: OR, 1.67 [95% CI, 1.03-2.69]; sleep time in apnea or hypopnea: OR, 1.79 [95% CI, 1.01-3.20]).

    Source:  Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 2011;306(6):613-9. doi: 10.1001/jama.2011.1115. (Table 3) Copyright © (2011) American Medical Association. All rights reserved.

  • Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study

    Association of self-reported sleep duration and 24-hour urine free cortisol among those without depression and those without a history of CVD.

    24-hour urine free cortisol results are adjusted means (95% confidence intervals). Results for the not depressed sub-group adjusted for age, race, apnea-hypopnea index, BMI, history of CVD and physical activity. Results from those without a history of CVD adjusted for age, race, apnea-hypopnea index, BMI, physical activity, and number of depressive symptoms.

    Source:  Rao MN, Blackwell T, Redline S, Punjabi NM, Barrett-Connor E, Neylan TC, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study. PLoS One 2013;8(9):e75205. doi: 10.1371/journal.pone.0075205. (Figure 1)

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Research Overview

  • Dr. Stone conducts large-scale multi-center cohort studies exploring the relationships between sleep and age-related health outcomes including cognitive impairment and dementia, cardiovascular disease, and mortality.
  • In collaboration with Drs. Steve Cummings and Greg Tranah at the San Francisco Coordinating Center, Dr. Stone’s studies are being analyzed to determine genes linked to insomnia, sleep apnea, and other sleep disturbances. Results of these investigations may yield new targets for sleep disorder therapies.
  • Dr. Stone is planning randomized trials to evaluate the effectiveness of treatments for sleep disorders in older adults, and their impact on cognitive function, risk of falls, and other health-related outcomes.
  • A charter member of the National Institutes of Health: Cardiovascular and Sleep Epidemiology Study Section, Dr. Stone is Co-chair of the Clinical Trials Outcomes Working Group of the National Sleep Research Network. She serves on the advisory board of CPMC’s Brain Health Center.

Learn more about research in the Center for Research on Human Aging.


Training

Dr. Stone received her M.A. in biostatistics and her Ph.D. in epidemiology from the University of California, Berkeley.


 

Publication Search

Publications

Kabat GC, Xue X, Kamensky V, Zaslavsky O, Stone KL, Johnson KC, Wassertheil-Smoller S, Shadyab AH, Luo J, Hale L, Qi L, Cauley JA, Brunner RL, Manson JE, Rohan TE, The association of sleep duration and quality with all-cause and cause-specific mortality in the Women's Health Initiative. Sleep Med

Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K, Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol

Mariani S, Tarokh L, Djonlagic I, Cade BE, Morrical MG, Yaffe K, Stone KL, Loparo KA, Purcell SM, Redline S, Aeschbach D, Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med

Langsetmo L, Kats AM, Cawthon PM, Cauley JA, Vo TN, Taylor BC, Stefanick ML, Lane NE, Stone KL, Orwoll ES, Schousboe JT, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Group., The Association Between Objectively Measured Physical Activity and Subsequent Health Care Utilization in Older Men. J Gerontol A Biol Sci Med Sci

Duarte S, Hoang T, Ewing SK, Cawthon PM, Cummings S, Stone KL, Cauley JA, Bauer DC, Hillier TA, Yaffe K, Glycated peptide levels are associated with cognitive decline among non-diabetic older women. J Gerontol A Biol Sci Med Sci

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Katie L. Stone, Ph.D., Senior Scientist
Primary Research Interests
  • Sleep and age-related health outcomes