Peggy Cawthon, Ph.D., M.P.H., Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Using large-cohort studies to understand age-related physical decline
  • Predicted probability of frailty status at follow-up

    Predicted probability of frailty status at follow-up, by quartile of bioavailable testosterone and frailty status at baseline for a 73.4-yr-old man. Cut-points for quartiles of bioavailable testosterone: Q1, _165.4 ng/dl; Q2, 165.4 to _201.5 ng/dl; Q3, 201.5 to _241.9 ng/dl; and Q4, _241.9 ng/dl. Probabilities derived from a partial proportional odds model, with age and bioavailable testosterone meeting the proportionality assumption, and frailty status at baseline not meeting the proportional odds assumption. The age assumed for the model (73.4 yr) is the mean age of the population at baseline.
    Source: Cawthon PM, et al, for the Osteoporotic Fractures in Men (MrOS) Research Group. J Clin Endocrinol Metab October 2009, 94(10):0000–0000. (Figure 3) First published ahead of print September 15, 2009 as doi:10.1210/jc.2009-0417

  • Adjusted survival plots for participants in the MrOS study

    Adjusted survival plots for participants in the MrOS study, by quartile of total intact PTH or 25(OH)D. Plots are adjusted for age, clinic, season of blood draw, serum calcium and phosphate, GFR, percentage body fat, weight, race, health status, presence of at least one medical condition, alcohol use, education, activity level (PASE score), marital status, and presence of a functional or mobility limitation.

    Source: Cawthon PM, et al, for the Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25-Hydroxyvitamin D, Parathyroid Hormone, and Mortality in Older Men. J Clin Endocrinol Metab October 2010, 95(10):4625–4634. (Figure 1)

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Research Overview

  • Dr. Cawthon’s research on sarcopenia and age-related physical decline showed that tests of muscle strength and walking speed can help predict disability in older adults.
  • Using data from several ongoing large-cohort studies, she and colleagues at the San Francisco Coordinating Center (SFCC) study bone loss in older men; the association between vitamin D and mortality; risk factors for osteoporotic fractures in older women and men; and predictors of frailty in the elderly.
  • As part of her role at the SFCC, Dr. Cawthon co-leads multi-center observational studies, including the Study of Osteoporosis in Men (MrOS) and the Study of Osteoporotic Fractures (SOF) in women, and has analyzed data from the Health, Aging and Body Composition (Health ABC) and Framingham studies.

Learn more about research in the Center for Research on Human Aging.

A new documentary features Dr. Cawthon and other aging and longevity experts at CPMCRI. Review a blog post that describes the documentary and includes a link to the trailer. 


Training


Dr. Cawthon received her Ph.D. and M.P.H. from the University of California, Berkeley.


 

Publication Search

Publications

Harvey NC, Odén A, Orwoll E, Lapidus J, Kwok T, Karlsson MK, Rosengren BE, Ribom E, Cooper C, Cawthon PM, Kanis JA, Ohlsson C, Mellström D, Johansson H, McCloskey E, Measures of physical performance and muscle strength as predictors of fracture risk independent of FRAX, falls and BMD: A meta-analysis of the Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res

Cawthon PM, Orwoll ES, Peters KE, Ensrud KE, Cauley JA, Kado DM, Stefanick ML, Shikany JM, Strotmeyer ES, Glynn NW, Caserotti P, Shankaran M, Hellerstein M, Cummings SR, Evans WJ, Osteoporotic Fractures in Men (MrOS) Study Research Group., Strong Relation between Muscle Mass Determined by D3-creatine Dilution, Physical Performance and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men. J Gerontol A Biol Sci Med Sci

Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K, Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol

Langsetmo L, Kats AM, Cawthon PM, Cauley JA, Vo TN, Taylor BC, Stefanick ML, Lane NE, Stone KL, Orwoll ES, Schousboe JT, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Group., The Association Between Objectively Measured Physical Activity and Subsequent Health Care Utilization in Older Men. J Gerontol A Biol Sci Med Sci

Cauley JA, Burghardt AJ, Harrison SL, Cawthon PM, Schwartz AV, Connor EB, Ensrud KE, Langsetmo L, Majumdar S, Orwoll E, Osteoporotic Fractures in Men (MrOS) Research Group., Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength. J Bone Miner Res

Duarte S, Hoang T, Ewing SK, Cawthon PM, Cummings S, Stone KL, Cauley JA, Bauer DC, Hillier TA, Yaffe K, Glycated peptide levels are associated with cognitive decline among non-diabetic older women. J Gerontol A Biol Sci Med Sci

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Peggy Cawthon, Ph.D., M.P.H., Senior Scientist
Primary Research Interests
  • Sarcopenia and age-related physical decline
  • The association between vitamin D and mortality
  • Risk factors for osteoporotic fractures in older women and men