Steven Cummings, M.D. , Director of the San Francisco Coordinating Center; Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Investigating the genetic variants controlling longevity and aging
  • Incidence of invasive breast cancer

    Incidence of invasive breast cancer as a function of age and breast density in U.S. women.
    BI-RADS = Breast Imaging Reporting and Data System; SEER = Surveillance, Epidemiology, and End Results. * Per 10 000 women per year.

    Source: Schousboe JT, Kerlikowske K, Loh A, Cummings SR. Personalizing Mammography by Breast Density and Other Risk Factors for Breast Cancer: Analysis of Health Benefits and Cost-Effectiveness. Ann Intern Med 2011:5;155(1):10-20. (Figure 2)

  • Percent fibroglandular volume and fibroglandular volume

    Percent fibroglandular volume and fibroglandular volume, plotted as the log value, compared to percent dense area. Although percent fibroglandular volume was highly correlated to percent dense area, the log (fibroglandular volume) weakly correlated.

    Source: Shepherd JA, Kerlikowske K, Ma L, Duewer F, Fan B, Wang J, Malkov S, Vittinghoff E, Cummings SR. Volume of Mammographic Density and Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev 2011:20(7);1473-1482. (Figure 1)

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Research Overview

As Director of the San Francisco Coordinating Center (SFCC)—a joint research initiative of CPMCRI and the University of California at San Francisco’s Department of Epidemiology and Biostatistics—Dr. Cummings leads multi-center studies in women’s and men’s health, aging, cognitive function, cardiovascular disease, breast cancer prevention, osteoporosis, arthritis, and dementia.

  • SFCC is the lead facility for a major National Institute on Aging sponsored effort via the Longevity Consortium, designed to identify genes controlling longevity and aging.  Dr. Cummings and colleagues have developed a network of studies on the genomes of centenarians, to increase understanding of the genetic pathways that control age-related illnesses.
  • Dr. Cummings leads the Osteoporotic Fractures in Men (MrOS) project—a prospective cohort study designed to examine the extent to which fracture risk is related to bone mass, bone geometry, lifestyle, neuromuscular measures, and fall propensity; and to determine how fractures affect quality of life in older men.
  • He is a principal investigator of the Health, Aging, and Body Composition (Health ABC) study—an observational study of the onset of physical disability in relation to body composition change, particularly loss of muscle mass (or, sarcopenia) in old age.
  • In collaboration with SFCC scientist Dr. Katie Stone, Dr. Cummings is exploring the relationship between sleep disorders and/or quality of sleep, and the risk of cardiovascular disease, osteoporosis, falls, and decline in cognitive function.
  • With support from the Daniel and Phyllis Da Costa Fund, Dr. Cummings partners with researchers at the Royal Marsden Hospital in London. Together, they are investigating strategies to prevent breast cancer, and developing new means to identify women at high risk of the illness.
  • Dr. Cummings has over 25 years’ experience leading multicenter observational studies and clinical trials, and he is pursuing new initiatives designed to increase the efficiency and cost-effectiveness of clinical trials.

Learn more about research in the Center for Research on Human Aging.

A new documentary features Dr. Cummings and other aging and longevity experts at CPMCRI. Review a blog post that describes the documentary and includes a link to the trailer. 


Training


Dr. Cummings completed his residency in Internal Medicine, and a Fellowship in Clinical Epidemiology at UCSF. He served as Chief of General Internal Medicine and Associate Chair of Medicine for Clinical Research, and co-founded the Postgraduate Clinical Research Training Program at UCSF. He is a Professor Emeritus of Medicine, Epidemiology and Biostatistics at UCSF.


 

Publication Search

Publications

Cummings SR, Ferrari S, Brown JP, Wang AT, Response to Dr. Lamy and Dr. Gonzalez-Rodriguez. J Bone Miner Res

Orwoll ES, Wiedrick J, Jacobs J, Baker ES, Piehowski P, Petyuk V, Gao Y, Shi T, Smith RD, Bauer DC, Cummings SR, Nielson CM, Lapidus J, Osteoporotic Fractures in Men Study (MrOS) Research Group., High-throughput serum proteomics for the identification of protein biomarkers of mortality in older men. Aging Cell

Bonham LW, Evans DS, Liu Y, Cummings SR, Yaffe K, Yokoyama JS, Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen

Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, Thalamuthu A, Mangino M, Liu J, Demirkan A, Lek M, Xu L, Wang G, Oldmeadow C, Gaulton KJ, Lotta LA, Miyamoto-Mikami E, Rivas MA, White T, Loh PR, Aadahl M, Amin N, Attia JR, Austin K, Benyamin B, Brage S, Cheng YC, Cięszczyk P, Derave W, Eriksson KF, Eynon N, Linneberg A, Lucia A, Massidda M, Mitchell BD, Miyachi M, Murakami H, Padmanabhan S, Pandey A, Papadimitriou I, Rajpal DK, Sale C, Schnurr TM, Sessa F, Shrine N, Tobin MD, Varley I, Wain LV, Wray NR, Lindgren CM, MacArthur DG, Waterworth DM, McCarthy MI, Pedersen O, Khaw KT, Kiel DP, GEFOS Any-Type of Fracture Consortium., Pitsiladis Y, Fuku N, Franks PW, North KN, van Duijn CM, Mather KA, Hansen T, Hansson O, Spector T, Murabito JM, Richards JB, Rivadeneira F, Langenberg C, Perry JRB, Wareham NJ, Scott RA, Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nat Commun

Stone KL, Lui LY, Christen WG, Troen AM, Bauer DC, Kado D, Schambach C, Cummings SR, Manson JE, Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial. J Bone Miner Res

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