Steven Cummings, M.D. , Director of the San Francisco Coordinating Center; Senior Scientist

California Pacific CURRENTS: The online journal of CPMC Research Institute

Investigating the genetic variants controlling longevity and aging
  • Incidence of invasive breast cancer

    Incidence of invasive breast cancer as a function of age and breast density in U.S. women.
    BI-RADS = Breast Imaging Reporting and Data System; SEER = Surveillance, Epidemiology, and End Results. * Per 10 000 women per year.

    Source: Schousboe JT, Kerlikowske K, Loh A, Cummings SR. Personalizing Mammography by Breast Density and Other Risk Factors for Breast Cancer: Analysis of Health Benefits and Cost-Effectiveness. Ann Intern Med 2011:5;155(1):10-20. (Figure 2)

  • Percent fibroglandular volume and fibroglandular volume

    Percent fibroglandular volume and fibroglandular volume, plotted as the log value, compared to percent dense area. Although percent fibroglandular volume was highly correlated to percent dense area, the log (fibroglandular volume) weakly correlated.

    Source: Shepherd JA, Kerlikowske K, Ma L, Duewer F, Fan B, Wang J, Malkov S, Vittinghoff E, Cummings SR. Volume of Mammographic Density and Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev 2011:20(7);1473-1482. (Figure 1)

+

Research Overview

As Director of the San Francisco Coordinating Center (SFCC)—a joint research initiative of CPMCRI and the University of California at San Francisco’s Department of Epidemiology and Biostatistics—Dr. Cummings leads multi-center studies in women’s and men’s health, aging, cognitive function, cardiovascular disease, breast cancer prevention, osteoporosis, arthritis, and dementia.

  • SFCC is the lead facility for a major National Institute on Aging sponsored effort via the Longevity Consortium, designed to identify genes controlling longevity and aging.  Dr. Cummings and colleagues have developed a network of studies on the genomes of centenarians, to increase understanding of the genetic pathways that control age-related illnesses.
  • Dr. Cummings leads the Osteoporotic Fractures in Men (MrOS) project—a prospective cohort study designed to examine the extent to which fracture risk is related to bone mass, bone geometry, lifestyle, neuromuscular measures, and fall propensity; and to determine how fractures affect quality of life in older men.
  • He is a principal investigator of the Health, Aging, and Body Composition (Health ABC) study—an observational study of the onset of physical disability in relation to body composition change, particularly loss of muscle mass (or, sarcopenia) in old age.
  • In collaboration with SFCC scientist Dr. Katie Stone, Dr. Cummings is exploring the relationship between sleep disorders and/or quality of sleep, and the risk of cardiovascular disease, osteoporosis, falls, and decline in cognitive function.
  • With support from the Daniel and Phyllis Da Costa Fund, Dr. Cummings partners with researchers at the Royal Marsden Hospital in London. Together, they are investigating strategies to prevent breast cancer, and developing new means to identify women at high risk of the illness.
  • Dr. Cummings has over 25 years’ experience leading multicenter observational studies and clinical trials, and he is pursuing new initiatives designed to increase the efficiency and cost-effectiveness of clinical trials.

Learn more about research in the Center for Research on Human Aging.

A new documentary features Dr. Cummings and other aging and longevity experts at CPMCRI. Review a blog post that describes the documentary and includes a link to the trailer. 


Training


Dr. Cummings completed his residency in Internal Medicine, and a Fellowship in Clinical Epidemiology at UCSF. He served as Chief of General Internal Medicine and Associate Chair of Medicine for Clinical Research, and co-founded the Postgraduate Clinical Research Training Program at UCSF. He is a Professor Emeritus of Medicine, Epidemiology and Biostatistics at UCSF.


 

Publication Search

Publications

Shieh Y, Hu D, Ma L, Huntsman S, Gard CC, Leung JWT, Tice JA, Ziv E, Kerlikowske K, Cummings SR, Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones. Breast Cancer Res Treat

Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P, PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites. Circ Cardiovasc Genet

Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker S, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stančáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP, Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun

Black DM, Cauley JA, Wagman R, Ensrud K, Fink HA, Hillier TA, Lui LY, Cummings SR, Schousboe JT, Napoli N, The Ability of a Single BMD and Fracture History Assessment to Predict Fracture Over 25 Years in Postmenopausal Women: The Study of Osteoporotic Fractures. J Bone Miner Res

Seyerle AA, Sitlani CM, Noordam R, Gogarten SM, Li J, Li X, Evans DS, Sun F, Laaksonen MA, Isaacs A, Kristiansson K, Highland HM, Stewart JD, Harris TB, Trompet S, Bis JC, Peloso GM, Brody JA, Broer L, Busch EL, Duan Q, Stilp AM, O'Donnell CJ, Macfarlane PW, Floyd JS, Kors JA, Lin HJ, Li-Gao R, Sofer T, Méndez-Giráldez R, Cummings SR, Heckbert SR, Hofman A, Ford I, Li Y, Launer LJ, Porthan K, Newton-Cheh C, Napier MD, Kerr KF, Reiner AP, Rice KM, Roach J, Buckley BM, Soliman EZ, de Mutsert R, Sotoodehnia N, Uitterlinden AG, North KE, Lee CR, Gudnason V, Stürmer T, Rosendaal FR, Taylor KD, Wiggins KL, Wilson JG, Chen YD, Kaplan RC, Wilhelmsen K, Cupples LA, Salomaa V, van Duijn C, Jukema JW, Liu Y, Mook-Kanamori DO, Lange LA, Vasan RS, Smith AV, Stricker BH, Laurie CC, Rotter JI, Whitsel EA, Psaty BM, Avery CL, Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SLR, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G, Correction: The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY)

VIEW ALL