Garret L. Yount, Ph.D., Senior Scientist; Director of the Mind-Body Medicine Research Group at CPMC

California Pacific CURRENTS: The online journal of CPMC Research Institute

Molecular and cellular biology of cancers, and mind-body approaches to health and well-being
  • Transcription initiation RNA (tiRNA) expression in human glioblastoma cells

    Transcription initiation RNA (tiRNA) expression in human glioblastoma cells. Non-coding RNAs are emerging as key elements of cellular homeostasis and carcinogenesis. Transcription initiation RNAs (tiRNAs) are newly-discovered nuclear localized 18 nucleotide RNAs derived from sequences immediately downstream of the RNA polymerase II transcription start sites (shown as a red vertical line). The 5’ ends of small RNAs detected in U251 glioblastoma cells are plotted to show their relationship to the transcription start site. Small RNA sizes are shown as individual colors.

  • genes that could contribute to the development post-traumatic stress disorder

    Theoretical framework used to evaluated genes that could contribute to the development post-traumatic stress disorder (PTSD) based on their potential regulatory links between the hypothalamic-pituitary axis (HPA), autonomic nervous system (ANS), and inflammatory systems.

    Source: Hollifield M, Moore D, Yount G. Gene expression analysis in combat veterans with and without post-traumatic stress disorder. Mol Med Rep 2013;8(1):238-44.

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Research Overview

  • Current research in the Yount lab focuses on understanding cancer cell metastasis; the role of independent motile microplasts in the migration of brain tumor cells; treatment of glioblastoma multiforme with camptothecin and other herbal compounds used in Traditional Chinese Medicine; and evaluating the evidence for a human biofield that can be manipulated to influence healing processes.
  • Leading the Mind-Body Medicine Research Group and collaborating with the Institute for Health and Healing at CPMC, Dr. Yount studies physiologic and genomic changes associated with stress reduction and positive emotions, and how these changes are affected by novel interventions including music and expressive arts therapy.
  • Dr. Yount’s lab developed a saliva-based test to measure epigenetic changes in patients non-invasively, and the test is being investigated for use as a diagnostic in pediatric Crohn’s disease.

Training

Dr. Yount studied molecular and cellular biology at Pennsylvania State University, before completing a Ph.D. in Neurobiology and Behavior at the State University of New York at Stony Brook. During his postdoctoral training at the University of California, San Francisco, he was awarded a fellowship from the Robert Steel Foundation for Pediatric Cancer Research.




 

Publication Search

Publications

Soroceanu L, Murase R, Limbad C, Singer E, Allison J, Adrados I, Kawamura R, Pakdel A, Fukuyo Y, Nguyen D, Khan S, Arauz R, Yount GL, Moore DH, Desprez PY, McAllister SD, Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target. Cancer Res

Hammerschlag R, Jain S, Baldwin AL, Gronowicz G, Lutgendorf SK, Oschman JL, Yount GL, Biofield research: a roundtable discussion of scientific and methodological issues. J Altern Complement Med

Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J, Pakdel A, Allison J, Limbad C, Moore DH, Yount GL, Desprez PY, McAllister SD, Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther

Afshar G, Jelluma N, Yang X, Basila D, Arvold ND, Karlsson A, Yount GL, Dansen TB, Koller E, Haas-Kogan DA, Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cells. Cancer Res

Schlitz M, Radin D, Malle BF, Schmidt S, Utts J, Yount GL, Distant healing intention: definitions and evolving guidelines for laboratory studies. Altern Ther Health Med

Hintz KJ, Yount GL, Kadar I, Schwartz G, Hammerschlag R, Lin S, Bioenergy definitions and research guidelines. Altern Ther Health Med

Garret L. Yount, Ph.D., Senior Scientist; Director of the Mind-Body Medicine Research Group at CPMC
Primary Research Interests
  • Molecular and cellular biology of cancers
  • Mind-body approaches to health and well-being
  • Gene expression changes associated with stress

Lab Members

Stephen Madamba, B.Sc.
Intern
Kenneth Rachlin, MSEE
Intern