Brain Health Clinical Trials

California Pacific CURRENTS: The online journal of CPMC Research Institute

Below is a listing of Alzheimer's disease and dementia clinical trials  approved by CPMC’s Institutional Review Board:

Imaging Dementia – Evidence for Amyloid Scanning (IDEAS) Study (IDEAS)

Description: The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) Study will establish an open-label, longitudinal cohort study to assess the impact of amyloid PET on patient outcomes.

Investigators

  • Dr. Alireza Atri

Eligibility Requirements

Patients 65 yrs. and older. Participants must be Medicare beneficiaries referred by qualified dementia specialists and must meet AUC for amyloid PET (Johnson et al. 2013).

Status

Open and enrolling.

Contacts

Amber Lee (LeeAJ@sutterhealth.org) 415-600-5568

Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients with Mild Alzheimer’s Disease

Description: This is a study to evaluate the efficacy and safety of azeliragon in patients with mild Alzheimer's disease. Patients will receive either azeliragon or placebo with a patient's participation lasting approximately 18 months.

Investigators

  • Dr. Alireza Atri

Eligibility Requirements

Patients 50 yrs. and older with a diagnosis of probable Alzheimer Disease (AD) with documented evidence of progression of disease.

Status

Open and enrolling.

Contacts

Contact: Amber Lee (LeeAJ@sutterhealth.org) 415-600-5568

A Clinico-Pathological Study of the Correspondence Between 18F-AV-1451 PET Imaging and Post-Mortem Assessment of Tau Pathology

Description: This study is designed to test the relationship between ante-mortem 18F-AV-1451 Positron Emission Tomography (PET) imaging and tau neurofibrillary pathology associated with Alzheimer's disease (AD), as measured at autopsy

Investigators

  • Alireza Atri, MD, PhD

Eligibility Requirements

Subjects 50 years and older who have a projected life expectancy of ≤ 6 months and who can tolerate a 20 minute PET scan

Status

Active and open to enrollment

Contacts

Amber Lee, 415-600-5568