Stroke / Neuro Critical Care Clinical Trials

California Pacific CURRENTS: The online journal of CPMC Research Institute

Below is a listing of Stroke / Neuro Critical Care clinical trials approved by CPMC’s Institutional Review Board:

 

Diffusion Weighted Imaging (DWI) or Computerized Tomography Perfusion (CTP) Assessment With Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention (DAWN Study)

Description: The purpose of the study is to evaluate the hypothesis that Trevo thrombectomy plus medical management leads to superior clinical outcomes at 90 days as compared to medical management alone in appropriately selected subjects experiencing an acute ischemic stroke when treatment is initiated within 6-24 hours after last seen well.

Investigators

Eligibility Requirements

Subjects 18 years of age and older with clinical signs and symptoms consistent with the diagnosis of an acute ischemic stroke

Status

Active and open to enrollment

Contacts

Douglas Raggett, RN, 415-600-3777

 

Stryker Neurovascular Trevo® Retriever Registry

Description: The purpose of the Trevo® Retriever Registry is to collect real world performance data of the Trevo Retriever which is intended to restore blood flow in the neurovasculature by removing thrombus in patients experiencing ischemic stroke

Investigators

  • Joey English, MD

Eligibility Requirements

Subjects experiencing acute ischemic stroke who are eligible for restoration of blood flow using any approved Trevo Retriever in the neurovasculature to remove thrombus

Status

Active and open to enrollment

Contacts

Wilson Ling, 415-600-3148

 

Expanding the Time Window for IV Thrombolysis with rt-PA in Acute Ischemic Stroke Patients Using Computed Tomography Perfusion Imaging: The PERFusion Use in Stroke Evaluation (PERFUSE) Study

Description: Patients with ischemic stroke who can be treated within six hours of symptom onset

Investigators

Eligibility Requirements

Acute Ischemic Stroke (AIS) patients, ≥ 18 years old, who present up to 6 hours from time of onset of acute stroke symptoms

Status

Active and open to enrollment

Contacts

Katie Ponting, 415-600-1163

COMPASS Trial: a Direct Aspiration First Pass Technique

Description: This is a prospective, randomized trial comparing mechanical thrombectomy with the ADAPT approach to stent retrievers in patients presenting with AIS within 6 hours of symptom onset

Investigators

  • Joey English, MD

Eligibility Requirements

Subjects, 18 y/o and older, with acute ischemic stroke, NIHSS ≥8 at the time of neuroimaging and persistent symptoms within 6 hours of when groin puncture can be obtained

Status

Active and open to enrollment

Contacts

Douglas Raggett, RN, 415-600-3777

 

A Phase 2a, Randomized, Double-Blind, Placebo-Controlled 21-Day Treatment Study, Including an fMRI Sub-Study, to Evaluate the Effect of HT-3951 on Upper Extremity Motor Function Following Ischemic Stroke (RESTORE)

Description: This is a randomized, double-blind, placebo-controlled parallel group outpatient study that will utilize standard stroke rehabilitation outcome measures, as well as fMRI techniques in a subset of subjects, to evaluate the effect of HT-3951 on motor recovery and behavior in medically stable subjects following ischemic stroke

Investigators

Eligibility Requirements

Subjects, 40 to 85 y/o, who have experienced an ischemic stroke documented by CT or MRI with size of the lesion ≤ 60 cc resulting in an upper extremity deficit that, in the opinion of the Investigator, warrants the need for rehabilitation therapy

Status

Active and open to enrollment

Contacts

Melissa Machado, 415-600-3709